Connie Mason, playing the part of Terry Adams, was Playboy magazine's Playmate of the Month for its June 1963 issue.
Director Herschell Gordon Lewis novelized his screenplay into a tie-in book, the original edition of which is now in high demand by collectors
Director Herschell Gordon Lewis has often cited Two Thousand Maniacs! as his personal favorite of his films.
Film debut of Illinois stage actor Taalkeus 'Talky' Blank (Jeffrey Allen), whom played Mayor Buckman, and whom would later appear playing numerous Southern-accented characters in several of Herschell Gordon Lewis' movies.
Filmed in 14 days.
Many of the buildings from this movie, including the Hunter Arms Hotel where a large portion of it was filmed, still exist in downtown St. Cloud, Florida.
The comic book Harper is reading in the hotel is "Heart Throbs," issue 87, cover dated December 1963-January 1964.
The plot of this gore film was inspired by the musical Brigadoon.
This film inspired the name of American alt-rock band 10,000 Maniacs.
This film was reportedly shot in an area of Florida that is now occupied by Walt Disney World.