According to Don Knotts' autobiography, the off-screen voice yelling, "Attaboy, Luther!" belongs to screenwriter Everett Greenbaum.
Besides Don Knotts, there are a number of actors from the Andy Griffith Show in this movie, some playing characters very similar to the characters they did in the Andy Griffith Show. For example, Hal Smith plays the town drunk in both productions, and Dorthy Neumann plays Smith's wife in both productions. Also, "Griffith" show veterans, such as Burt Mustin and Hope Summers are featured in this movie. This was Knott's first film after leaving the Andy Griffith Show.
Charles Lane, another Andy Griffith alumni (Mr. Frisby), also makes an appearance as Lawyer Whitlow.
Contrary to some belief, the exterior of the Simmons house was not the same one built for Alfred Hitchcock's Psycho. The Simmons house is a different facade located on what used to be named Colonial Street on Universal's back lot, and has been used in several other shows.
One of the few American films shot in the Technicolor Corporation's Techniscope wide screen process. The wide screen effect was achieved by essentially splitting the usual film frame horizontally into two smaller frames with a greater width to height ratio. It was inexpensive, but yielded a grainy image, which probably explains why it was seldom used in Hollywood.
The car Luther Heggs drives is an Edsel, a short lived marque of the Ford Corporation named after Henry Ford's son, Edsel Ford.
The mansion seen in the opening shots is also best known at the home of the Munsters in the TV show, "The Munsters."
The outside street scenes in the opening credits to "The Ghost and Mr Chicken" were filmed at Universal Studios Back lot. The mansion shown is the Harvey House, now seen in Desperate Housewives.
The street used for the film was also used in The Burbs.
This film inspired a short-lived craze for yelling out "Attaboy, (name)" during speeches and other situations. This came from a running gag used in this film.