"Professional Sweetheart" was Ginger Rogers' first film for RKO and - ironically, since so much of the plot revolves around getting Rogers' character to sign a radio contract - she had not yet signed a long-term contract with RKO when she made this film.
Ginger Rogers was dubbed by Etta Moten; this is reputedly the only film in which Rogers did not do her own singing.
Working titles were "Careless" and then "The Purity Girl".