A vorvolakas (also vrykolakas) occurs in Greek folklore as an undead creature capable of causing harm to the living. Its characteristics are similar to many other characters of legend, but it is most closely associated with vampires. In Hollywood movies such as Dracula, the word vampire is often translated to Greek as vrykolakas. However, traditional vorvolakas are not noted for blood-drinking.
Filming began in July 1944, but was suspended when Boris Karloff required back surgery. It was completed in December 1944. After Karloff had recovered from surgery, but before the cast of Isle of the Dead could be reassembled, Val Lewton and Karloff made The Body Snatcher, which was released first.
The 19th century artist, Bocklin, painted "The Isle of the Dead." It appears in the credits of this film and is recreated in the sets.
The statue of the three-headed dog is of Cerberus who guards the gates of Hades to prevent anybody escaping back across the River Styx.